Kashiwag K., Shichino Y. (equal contribution), Osaki T. (equal contribution), Sakamoto A., Nishimoto M., Takahashi M., Mito M., Weber F., Ikeuchi Y., Iwasaki S.*, and Ito T.:
“eIF2B-capturing viral protein NSs suppresses the integrated stress response”
BioRxiv. (2021)
Mishima Y., Han P., Kimura S., and Iwasaki S.:
“Transient ribosome slowdown at the decoding step triggers mRNA degradation independent of Znf598 in zebrafish”
BioRxiv. (2021)
Makino S., Kawamata T., Iwasaki S.*, and Ohsumi Y.:
“Selectivity of mRNA degradation by autophagy in yeast”
Nat Commun. 12(1):2316. (2021)
Press Release (RIKEN)
Press Release (Tokyo Institute of Technology)
Editors’ Highlights
Yoshimoto R., Chhipi-Shrestha JK., Schneider-Poetsch T., Furuno M., Burroughs MA., Noma S., Suzuki H., Hayashizaki Y., Mayeda A., Nakagawa S., Kaida D., Iwasaki S.*, and Yoshida M.:
“Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation”
Cell Chem Biol. S2451-9456(21)00111-2. (2021)
Press Release
Chadani Y., Sugata N., Niwa T., Ito Y., Iwasaki S., and Taguchi H.:
“Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome”
BioRxiv. (2021)
Higashi H., Kato Y., Fujita T., Iwasaki S., Nakamura M., Nishimura Y., Takenaka M., and Shikanai T.:
“The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs”
Plant Cell Physiol. pcaa180. (2021)
Chen M., Asanuma M., Takahashi M., Shichino Y., Mito M., Fujiwara K., Saito H., Floor SN., Ingolia NT., Sodeoka M., Dodo K., Ito T., and Iwasaki S.*:
“Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A”
Cell Chem Biol. 28(4):475-486.e8. (2021)
Press Release
Journal Cover
Chhipi Shrestha JC., Schneider-Poetsch T., Suzuki T., Mito M., Kha K., Dohmae N., Iwasaki S.*, and Yoshida M.:
“Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns”
BioRxiv. (2020)
Mito M., Mishima Y., and Iwasaki S.*:
“Protocol for disome profiling to survey ribosome collision in humans and zebrafish”
STAR Protoc. 1:100168. (2020)
Matsuki Y., Matsuo y., Nakano Y., Iwasaki S., Yoko H., Udagawa T., Li S., Saeki Y., Yoshihisa T., Tanaka K., Ingolia NT., and Inada T.:
“Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome”
Sci Rep. 110(1):19669. (2020)
BioRxiv. (2020)
Wu Q., Shichino Y., Abe T., Suetsugu T., Omori A., Kiyonari H., Iwasaki S., and Matsuzaki F.:
“Selective translation of epigenetic modifiers drives the developmental clock of neural stem cells”
BioRxiv. (2020)
Iwakawa HO., Lam Y.W.A., Mine A., Fujita T., Kiyokawa K., Yoshikawa M., Takeda A., Iwasaki S., and Tomari Y.:
“Ribosome stalling caused by the Argonaute-miRNA-SGS3 complex regulates production of secondary siRNA biogenesis in plants”
BioRxiv. (2020)
Suzuki Ta., Yashiro Y., Kikuchi I., Ishigami Y., Saito H., Matsuzawa I., Okada S., Mito M., Iwasaki S., Ma D., Zhao X., Asano K., Lin H., Kirino Y., Sakaguchi Y., and Suzuki Ts.:
“Complete chemical structures of human mitochondrial tRNAs”
Nat Commun. 11(1):4269. (2020)
Press Release (The University of Tokyo)
Press Release (RIKEN)
Nakazawa K. Shichino Y., Iwasaki S., and Shiina N.:
“Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation”
J Biol Chem. 295(44):15029-15044. (2020)
Press Release (NIBB)
Press Release (RIKEN)
Saeki N., Eguchi Y., Kintaka R., Makanae K., Shichino Y., Iwasaki S., Kanno M., Kimura N., and Moriya H.:
“N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae
Sci Rep. 10(1):9500. (2020)
Han P., Shichino Y., Schneider-Poetsch T., Mito M., Hashimoto S., Udagawa T., Kohno K., Yoshida M., Mishima Y., Inada T., and Iwasaki S.*:
“Genome-wide survey of ribosome collision”
Cell Rep. 31(5):107610. (2020)
BioRxiv. (2019)
Press Release
Tsuboyama K., Osaki T., Matsuura-Suzuki E., Kozuka-Hata H., Okada Y., Oyama M., Ikeuchi Y., Iwasaki S., and Tomari Y.:
“A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation”
PLoS Biol. 18(3):e3000632. (2020)
BioRxiv. (2019)
Press Release (The University of Tokyo)
News (
Yokoi S, Naruse K, Kamei Y, Ansai S, Kinoshita M, Mito M, Iwasaki S., Inoue S, Okuyama T, Nakagawa S, Young LJ, and Takeuchi H.:
“Sexually dimorphic role of oxytocin in medaka mate choice”
Proc Natl Acad Sci USA. 117(9):4802-4808. (2020)
Kurihara Y., Makita Y., Shimohira H., Fujita T., Iwasaki S., and Matsui M.:
“Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis
Plant Cell Physiol. 61(3):536-545. (2020)
Press Release
Hia F., Yang SF., Shichino Y., Yoshinaga M., Murakawa Y., Vandenbon A., Fukao A., Fujiwara T., Landthaler M., Natsume N., Adachi S., Iwasaki S., and Takeuchi O.:
“Codon bias confers stability to human mRNAs”
EMBO. Rep. 20(11):e48220. (2019)
BioRxiv. (2019)
Padrón A., Iwasaki S., and Ingolia NT.:
“Proximity RNA labeling by APEX-Seq reveals the organization of translation initiation complexes and repressive RNA granules”
Mol. Cell. 75(4):875-887. (2019)
BioRxiv. (2018)
Hirayama H., Matsuda T., Tsuchiya Y., Oka R., Seino J., Huang C., Nakajima K., Noda Y., Shichino Y., Iwasaki S., and Suzuki T.:
“Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast”
J Biol Chem. 294(44):15900-15911. (2019)
Selected as "Editors' Picks Highlights"
Press Release
Fujita T., Kurihara Y., and Iwasaki S.*:
“The plant translatome surveyed by ribosome profiling”
Plant Cell Physiol. 60(9):1917-1926. (2019)
Selected as "Editor's choice"
Mito M., Kadota M., Nakagawa S., and Iwasaki S.*:
“tChIP-Seq: cell-type-specific Eepigenome profiling”
J. Vis. Exp. 143:e58298. (2019)
Iwasaki S.*, Iwasaki W., Takahashi M. (equal contribution), Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T., and Ingolia NT.:
“The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA”
Mol. Cell. 73(4):738-748. (2019)
Press Release
Akichika S., Hirano S. (equal contribution), Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.:
“Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase”
Science. 363(6423):eaav0080. (2019)
Press Release (Nikkei)
Press Release (The University of Tokyo)
Press Release (RIKEN)
Komatsu T., Yokoi S., Mito M., Fujii K., Kimura Y., Iwasaki S., and Nakagawa S.:
“UPA-Seq: Prediction of functional lncRNAs using differential sensitivity to UV crosslinking”
RNA. 24(12):1785-1802. (2018)
BioRxiv (2018)
Kurihara Y., Makita Y., Kawashima M., Fujita T., Iwasaki S., and Matsui M.:
“Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis
Proc Natl Acad Sci U S A. 115(30):7831-7836 (2018)
Highlighted by COMMENTARY
Press Release
Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.:
“Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing”
Sci Rep. 8:1143. (2018)
BioRxiv. (2017)
Press Release
Iwasaki S. and Tomari Y.:
“Reconstitution of RNA interference machinery”
Methods Mol Biol.1680:131-143. (2018)
Naruse K., Matsuura-Suzuki E. (equal contribution), Watanabe M., Iwasaki S.*, and Tomari Y.:
“In vitro reconstitution of chaperone-mediated human RISC assembly”
RNA 24(1):6-11. (2018)
Matsuo Y., Ikeuchi K. (equal contribution), Saeki, Y., Iwasaki S., Schmidt C., Udagawa T., Sato F., Tsuchiya H., Becker T., Tanaka K., Ingolia NT., Beckmann R., and Inada T.:
“Ubiquitination of stalled ribosome triggers ribosome-associated quality control”
Nat Commun. 8(1):159. (2017)
Iwasaki S.* and Ingolia NT.:
“The Growing Toolbox for Protein Synthesis Studies”
Trends Biochem Sci. 42(8):612-624. (2017)
Ishikawa K., Makanae K., Iwasaki S., Ingolia NT., and Moriya H.:
“Post-translational dosage compensation buffers genetic perturbations to stoichiometry of protein complexes”
PLoS Genet. 13(1):e1006554. (2017)
Press Release (Okayama University)
News (QLifePro)
Iwasaki S. and Ingolia NT.:
“PROTEIN TRANSLATION. Seeing translation”
Science 352(6292):1391-2. (2016)
Iwasaki S., Floor SN., and Ingolia NT.:
“Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor”
Nature 534(7608):558-61. (2016)
Werner A., Iwasaki S., Teerikorpi N., Fedrigo I., Ingolia NT., and Rape M.:
“Cell-fate determination by ubiquitin-dependent regulation of translation”
Nature 525(7570):523-7. (2015)
Iwasaki S., Sasaki MH. (equal contribution), Sakaguchi Y., Suzuki T., Tadakuma H., and Tomari Y.:
“Defining fundamental steps in the assembly of Drosophila RNAi enzyme complex”
Nature 521(7553):533-6. (2015)
Press Release
Kwak PB., Iwasaki S. (equal contribution), and Tomari Y.:
“The microRNA pathway and cancer”
Cancer Sci. 101(11), 2309-15 (2010)
Iwasaki S., Kobayashi M. (equal contribution), Yoda M., Sakaguchi Y., Katsuma S., Suzuki T., and Tomari Y.:
“Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes”
Mol. Cell. 39(2):292-9. (2010)
Yoda M., Kawamata T., Paroo Z., Ye X., Iwasaki S., Liu Q., and Tomari Y.:
“ATP-dependent human RISC assembly pathways”
Nat. Struct. Mol. Biol. 17(1):17-23. (2010)
Iwasaki S., and Tomari Y.:
“Argonaute-mediated translational repression (and activation)”
Fly (Austin) 3(3):204-6. (2009)
Iwasaki S., Kawamata T., and Tomari Y.:
Drosophila Argonaute1 and Argonaute2 employ distinct mechanisms for translational repression”
Mol Cell. 34(1):58-67. (2009)
Journal Cover
Takeda A., Iwasaki S., Watanabe T., Utsumi M., and Watanabe Y.:
“The mechanism selecting the guide strand from small RNA duplexes is different among Argonaute proteins”
Plant Cell Physiol. 49(4):493-500. (2008)
Iwasaki S., Takeda A., Motose H., and Watanabe Y.:
“Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development”
FEBS Lett. 581(13):2455-9. (2007)
Japanese Reviews
七野悠一, 岩崎信太郎:
相分離生物学の全貌 (東京化学同人) 368-372. (2020)
木村悠介, 岩崎信太郎:
実験医学, 37(18):3055‐3057. (2019)
生化学 90(2):211‐215. (2018)
七野悠一, 岩崎信太郎:
実験医学, 35(11):1868‐1873. (2017)
“ncRNA判定法 (リボソームプロファイリング)”
ノンコーディングRNA RNA分子の全体像を俯瞰する (化学同人) 181-191. (2016)