Publications

Matsuura-Suzuki E., Kiyokawa K., Iwasaki S., and Tomari Y.*:
“The requirement of GW182 in miRNA-mediated gene silencing in Drosophila larval development”
EMBO J. (2024)
BioRxiv. (2024)

Kaneko S., Miyoshi K., Tomuro K., Terauchi M., Tanaka R., Kondo S., Tani N., Ishiguro K., Toyoda A., Kamikouchi A., Noguchi H., Iwasaki S., and Saito K.*:
“Mettl1-dependent m⁷G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogaster”
Nat Commun. 15(1):8147 (2024)
Press Release (NIG)
BioRxiv. (2023)

Saito H., Handa Y., Chen M., Schneider-Poetsch T., Shichino Y., Takahashi M., Romo D., Yoshida M., Fürstner A., Ito T., Fukuzawa K., and Iwasaki S.*:
“DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs”
Nat Commun. 15(1):7418 (2024)
Press Release (RIKEN)
Press Release (Osaka University)
BioRxiv. (2023)

Han P., Mito M., Ito T., and Iwasaki S.*:
“Sense codon-misassociated eRF1 elicits widespread ribosome stalling and induction of quality control”
BioRxiv. (2024)

Tomuro K., Mito M. (equal contribution), Toh H., Kawamoto N., Miyake T., Chow S.Y.A., Doi M., Ikeuchi Y., Shichino Y.*, and Iwasaki S.*:
“Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts”
Nat Commun. 15(1):7061 (2024)
Press Release (RIKEN)
Press Release (The University of Tokyo)
Press Release (Nikkei)
BioRxiv. (2024)

Tresky R., Miyamoto Y., Nagayoshi Y., Yabuki Y., Araki K., Takahashi Y., Komohara Y., Ge H., Nishiguchi K., Fukuda T., Kaneko H., Maeda N., Matsuura J., Iwasaki S., Sakakida K., Shioda N., Wei F.Y., Tomizawa K.*, Chujo T.*:
“TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice”
Nucleic Acids Res. 52(15):9230-9246 (2024)
Press Release (JST/Kumamoto University)

Ichinose T.*, Kondo S., Kanno M., Shichino Y., Mito M., Iwasaki S., and Tanimoto H.*:
“Translational regulation enhances distinction of cell types in the nervous system”
eLife. 12:RP90713 (2024)
BioRxiv. (2024)

Wakigawa T., Mito M. (equal contribution), Yamashiro H., Tomuro K., Tomizawa K., Chujo T., Nagao A., Suzuki Ta., Wei F.Y., Shichino Y., Suzuki Ts., and Iwasaki S.*:
“The complexity and dynamics of in organello translation assessed by high-resolution mitochondrial ribosome profiling”
BioRxiv. (2024)

Shichino Y.*, Yamaguchi T., Kashiwagi K., Mito M., Takahashi M., Ito T., Ingolia NT., Kuba K., and Iwasaki S.*:
“eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition”
Nat Struct Mol Biol. (2024)
Press Release (RIKEN)
BioRxiv. (2021)

Fujita T, Wakigawa T. (equal contribution), Kawamoto N., Kurihara Y., Hirose Y., Hirayama T., Toh H., Kuriyama T., Hashimoto A., Matsuura-Suzuki E., Mochida K., Yoshida M., Matsui M., and Iwasaki S.*:
“Synchronization between chloroplastic and cytosolic protein synthesis for photosynthesis complex assembly”
BioRxiv. (2024)

Toya H., Okamatsu-Ogura Y., Yokoi S., Kurihara M., Mito M., Iwasaki S., Hirose T., and Nakagawa S*.:
“The essential role of architectural noncoding RNA Neat1 in cold-induced beige adipocyte differentiation in mice”
RNA. 30(8):1011-1024 (2024)

Apostolopoulos A., Kawamoto N., Chow S.Y.A., Tsuiji H., Ikeuchi Y., Shichino Y.*, and Iwasaki S.*:
“dCas13-mediated translational repression for accurate gene silencing in mammalian cells”
Nat Commun. 15(1):2205 (2024)
Behind the Paper
Press Release (RIKEN)
Press Release (The University of Tokyo)
BioRxiv. (2023)

Kumakura N., Singkaravanit-Ogawa S., Gan P., Tsushima A., Ishihama N., Watanabe S., Seo M., Iwasaki S., Narusaka M., Narusaka Y., Takano Y, and Shirasu K.*:
“Guanosine-specific single-stranded ribonuclease effectors of a phytopathogenic fungus potentiate host immune responses”
New Phytol. 242(1):170-191 (2024)
BioRxiv. (2021)

Okubo C.*, Nakamura M., Sato M., Shichino Y., Mito M., Takashima Y., Iwasaki S., and Takahashi K*.:
“Selective translation orchestrates key signaling pathways in primed pluripotency.”
BioRxiv. (2024)

Ishibashi K., Shichino Y., Han P., Wakabayashi K., Inada T., Kimura S., Iwasaki S., and Mishima Y.*:
“Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in vertebrates.”
BioRxiv. (2024)

Tanaka M., Yokoyama T. (equal contribution), Saito H. (equal contribution), Nishimoto M., Tsuda K., Sotta N., Shigematsu H., Shirouzu M., Iwasaki S.*, Ito T.*, and Fujiwara T*.:
“Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.”
Nat Chem Biol. 20(5):605–614 (2024)
Press Release (RIKEN)
Press Release (The University of Tokyo)

Teyssonniere E.M., Shichino Y. (equal contribution), Mito M., Friedrich A., Iwasaki S.*, and Schacherer J.*:
“Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast.”
Nucleic Acids Res. 52(5):2434-2445 (2024)
BioRxiv. (2023)

Loughran G.*, Andreev D.E., Terenin I.M., Namy O., Mikl M., Yordanova M.M., McManus C.J., Firth A.E., Atkins J.F., Fraser C.S., Ignatova Z., Iwasaki S., Kufel J., Larson O., Leidel S.A., Mankin A.S., Mariotti M., Tanenbaum M.E., Topsirovic I., Vázquez-Laslop N., Viero G., Caliskan N., Chen Y., Clark P.L., Dinman J.D., Farabaugh P.J., Gilbert W.V., Ivanov P., Kieft J.S., Mühlemann O., Sachs M.S., Shatsky I.N., Sonenberg N., Steckelberg A.-L., Willis A.E., Woodside M.T., Valasek L.S.*, Dmitriev S.E.*, Baranov P.V.*.:
“Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).”
HAL. (2024)

Wakigawa T., Kimura Y. (equal contribution), Mito M., Tsubaki T., Lee M., Nakamura K., Khan A.H., Saito H., Yamamori T., Yamazaki T., Higashibata A., Tsuboi T., Hirabayashi Y., Takeuchi-Tomita N., Saito T., Higashitani A., Shichino Y., and Iwasaki S.*:
“Gravitational and mechanical forces drive mitochondrial translation.”
BioRxiv. (2024)

Matsumoto K.*, Kurokawa R., Takase M., Schneider-Poetsch T., Ling F., Suzuki T., Han P., Wakigawa T., Suzuki M., Tariq M., Ito A., Higashi K., Iwasaki S., Dohmae N., and Yoshida M.*:
“Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity.”
BioRxiv. (2023)

Yoshimoto R.*, Nakayama Y., Nomura I., Yamamoto I., Nakagawa Y., Tanaka S., Kurihara M., Suzuki Y., Kobayashi T., Kozuka-Hata H., Oyama M., Mito M., Iwasaki S., Yamazaki T., Hirose T., Araki K., and Nakagawa S.*:
“4.5SH RNA counteracts deleterious exonization of SINE B1 in mice.”
Mol Cell. S1097-2765(23)00964-4 (2023)
Press Release (Hokkaido University)
Press Release (RIKEN)
Research Square. (2022)
Sneak Peak. (2023)

Zhao X., Ma D. (equal contribution), Ishiguro K. (equal contribution), Saito H., Akichika S., Matsuzawa I., Mito M. Irie T., Ishibashi K., Wakabayashi K., Sakaguchi Y., Yokoyama T., Mishima Y., Shirouzu M., Iwasaki S., Takeo Suzuki Ta.*, and Suzuki Ts.*:
“Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth”
Cell. 186(25):5517-5535.e24 (2023)
Press Release (The University of Tokyo)
Press Release (RIKEN)
Press Release (Kyoto Sangyo University)

Matsuura-Suzuki E., Toh H. (equal contribution), and Iwasaki S.*:
“Human-rabbit hybrid translation system to explore the function of modified ribosomes”
Bio protoc. 13(13):e4714. (2023)

Schneider-Poetsch T.*, Dang Y., Arata M., Shichino Y., Mourabit A.A., Romo D., Liu J.O., Iwasaki S., and Yoshida M.*:
“Girolline is a sequence-context specific modulator of eIF5A activity”
Research Square. (2023)

Nagao A.*, Nakanishi Y., Yamaguchi Y., Mishina Y., Karoji M., Toya T., Fujita T., Iwasaki S., Miyauchi K., Sakaguchi Y., and Suzuki T.*:
“Quality control of protein synthesis in the early elongation stage”
Nat Commun. 14(1):2704 (2023)
Press Release (The University of Tokyo)
Press Release (Nikkei)

Kito Y., Matsumoto A. (equal contribution)*, Ichihara K., Shiraishi C., Tang R., Hatano A., Matsumoto M., Han P., Iwasaki S., and Nakayama KI.*:
“The ASC-1 complex promotes translation initiation by scanning ribosomes”
EMBO J. 42(12):e112869 (2023)
Press Release (RIKEN)
Press Release (Kyoto University)

Shiraishi C., Matsumoto A. (equal contribution)*, Ichihara K., Yamamoto T., Yokoyama T., Mizoo T., Hatano A., Matsumoto M., Tanaka Y., Matsuura-Suzuki E., Iwasaki S., Matsushima S., Tsutsui H., and Nakayama KI.*:
“RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function”
Nat Commun. 14(1):2131 (2023)
Press Release (RIKEN)
Press Release (Kyoto University)

Miyake T., Inoue Y. (equal contribution), Shao X., Seta T., Aoki Y., Nguyen Pham KT., Shichino Y., Sasaki J., Sasaki T., Ikawa M., Yamaguchi Y., Okamura H., Iwasaki S., and Doi M.*:
“Minimal upstream ORF of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm”
Cell Rep. 42(3):112157 (2023)
Press Release (Kyoto University)

Chen M., Kumakura N. (equal contribution), Muller R., Shichino Y., Nishimoto M., Mito M., Gan P., Ingolia NT., Shirasu K., Ito T., and Iwasaki S.*:
“A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants”
eLife. 12:e81302. (2023)
BioRxiv. (2022)
Press Release (RIKEN)
科学道2023 (RIKEN)
RIKEN Research Highlight (RIKEN)

Yamashita A., Shichino Y., Fujii K., Koshidaka Y., Adachi M., Sasagawa E., Mito M., Nakagawa S., Iwasaki S., Takao K., and Shiina N*.:
“ILF3 prion-like domain regulates gene expression and fear memory under chronic stress”
iScience. 26(3):106229. (2023)
Press Release (RIKEN)
Press Release (NIBB)

Saito H., Osaki T., Ikeuchi Y., and Iwasaki S.*:
“High-throughput assessment of mitochondrial protein synthesis in mammalian cells using mito-FUNCAT FACS”
Bio protoc. 13(3):e4602. (2023)
Journal Cover

Mito M., Shichino Y. (equal contribution), and Iwasaki S.*:
“Thor-Ribo-Seq: ribosome profiling tailored for low input with RNA-dependent RNA amplification”
BioRxiv. (2023)

Zhao T., Chida A. (equal contribution), Shichino Y. (equal contribution), Choi D., Mizunuma M., Iwasaki S., and Ohya Y.*:
“Multifarious translational regulation during replicative aging in yeast”
J Fungi (Basal). 8(9):938. (2022)

Chhipi-Shrestha JK., Yoshida M.*, and Iwasaki S.*:
“Filter trapping protocol to detect aggregated proteins in human cell lines”
STAR Protoc. 3(3):101571. (2022)

Matsuura-Suzuki E., Shimazu T. (equal contribution)*, Takahashi M., Kotoshiba K., Suzuki T., Kashiwagi K., Sohtome Y., Akakabe M., Sodeoka M., Dohmae N., Ito T.*, Shinkai Y.*, and Iwasaki S.*:
“METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance”
eLife. 11:e72780. (2022)
BioRxiv. (2021)
Press Release (RIKEN)

Yamada A., Toya H., Tanahashi M., Kurihara M., Mito M., Iwasaki S., Kurosaka S., Takumi T., Fox A., Kawamura Y., Miura K., and Nakagawa S.*:
“Species-specific formation of paraspeckles in intestinal epithelium revealed by characterization of NEAT1 in naked mole-rat”
RNA. 28(8):1128-1143. (2022)
RNA Journal Twitter (2022)
BioRxiv. (2022)

Shichino Y.* and Iwasaki S.*:
“Compounds for selective translational inhibition”
Curr Opin Chem Biol. 69:102158. (2022)

Fang Q., Kimura Y., Shimazu T., Suzuki T., Dohmae N., Iwasaki S., and Shinkai Y.*:
“HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors”
Sci Rep. 12(1):4104. (2022)
Research Square. (2021)

Kimura Y., Saito H. (equal contribution), Osaki T., Ikegami Y., Wakigawa T., Ikeuchi Y., and Iwasaki S.*:
“Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation”
RNA. 28(6):895-904. (2022)
RNA Journal Twitter (2022)
BioRxiv. (2022)

Apostolopoulos A. and Iwasaki S.*:
“Into the matrix: current methods for mitochondrial translation studies”
J Biochem. 171(4):379-387. (2022)

Wu Q., Shichino Y., Abe T., Suetsugu T., Omori A., Kiyonari H., Iwasaki S., and Matsuzaki F.*:
“Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells”
Nat Commun. 13(1):470. (2022)
BioRxiv. (2020)

Mishima Y.*, Han P., Ishibashi K., Kimura S., and Iwasaki S.:
“Ribosome slowdown triggers codon-mediated mRNA decay independently of ribosome quality control”
EMBO J. 41(5):e109256. (2022)
BioRxiv. (2021)
Press Release (RIKEN)
Press Release (Kyoto Sangyo University)
Research Results (AMED)

Fujita T., Yokoyama T., Shirouzu M., Taguchi H., Ito T., and Iwasaki S.*:
“The landscape of translational stall sites in bacteria revealed by monosome and disome profiling”
RNA. 28(3):290-302 (2022)
RNA Journal Twitter (2022)

Kashiwagi K., Shichino Y. (equal contribution), Osaki T. (equal contribution), Sakamoto A., Nishimoto M., Takahashi M., Mito M., Weber F., Ikeuchi Y.*, Iwasaki S.*, and Ito T.*:
“eIF2B-capturing viral protein NSs suppresses the integrated stress response”
Nat Commun. 12(1):7102. (2021)
BioRxiv. (2021)
Press Release (RIKEN)
Press Release (The University of Tokyo)
Research Results (AMED)
RIKEN Research Highlight (RIKEN)

Chadani Y.*, Sugata N., Niwa T., Ito Y., Iwasaki S., and Taguchi H.*:
“Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation”
EMBO J. 40(23):e108299. (2021)
BioRxiv. (2021)
Press Release (RIKEN)
Press Release (Tokyo Institute of Technology)

Chhipi-Shrestha JK., Schneider-Poetsch T., Suzuki T., Mito M., Kha K., Dohmae N., Iwasaki S.*, and Yoshida M.*:
“Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns”
Cell Chem Biol. 29(2):259-275.e10. (2022)
BioRxiv. (2020)
Press Release (RIKEN)
Press Release (The University of Tokyo)
Press Release (Nikkei)

Ichihara K., Matsumoto A.*, Nishida H., Kito Y., Shimizu H., Shichino Y., Iwasaki S., Imami K., Ishihama Y., and Nakayama KI.*:
“Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons”
Nucleic Acids Res. 49(13):7298-7317. (2021)
Press Release (RIKEN)
Press Release (Kyushu University)

Iwakawa HO.*, Lam Y.W.A., Mine A., Fujita T., Kiyokawa K., Yoshikawa M., Takeda A., Iwasaki S., and Tomari Y.:
“Ribosome stalling caused by the Argonaute-miRNA-SGS3 complex regulates production of secondary siRNA biogenesis in plants”
Cell Rep. 35(13):109300. (2021)
BioRxiv. (2020)
Press Release (RIKEN)
Press Release (The University of Tokyo)

Makino S., Kawamata T., Iwasaki S.*, and Ohsumi Y.*:
“Selectivity of mRNA degradation by autophagy in yeast”
Nat Commun. 12(1):2316. (2021)
Press Release (RIKEN)
Press Release (Tokyo Institute of Technology)
Editors’ Highlights
Recommended in Faculty Opinions

Yoshimoto R., Chhipi-Shrestha JK., Schneider-Poetsch T., Furuno M., Burroughs MA., Noma S., Suzuki H., Hayashizaki Y., Mayeda A., Nakagawa S., Kaida D., Iwasaki S.*, and Yoshida M.*:
“Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation”
Cell Chem Biol. 28(9):1356-1365.e4. (2021)
Press Release

Higashi H., Kato Y., Fujita T., Iwasaki S., Nakamura M., Nishimura Y., Takenaka M., and Shikanai T.*:
“The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs”
Plant Cell Physiol. 62(7):1146–1155. (2021)

Chen M., Asanuma M., Takahashi M., Shichino Y., Mito M., Fujiwara K., Saito H., Floor SN., Ingolia NT., Sodeoka M., Dodo K., Ito T., and Iwasaki S.*:
“Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A”
Cell Chem Biol. 28(4):475-486.e8. (2021)
Press Release
Journal Cover
Preview

Mito M., Mishima Y., and Iwasaki S.*:
“Protocol for disome profiling to survey ribosome collision in humans and zebrafish”
STAR Protoc. 1(3):100168. (2020)

Matsuki Y., Matsuo y., Nakano Y., Iwasaki S., Yoko H., Udagawa T., Li S., Saeki Y., Yoshihisa T., Tanaka K., Ingolia NT., and Inada T.*:
“Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome”
Sci Rep. 110(1):19669. (2020)
BioRxiv. (2020)

Suzuki Ta., Yashiro Y., Kikuchi I., Ishigami Y., Saito H., Matsuzawa I., Okada S., Mito M., Iwasaki S., Ma D., Zhao X., Asano K., Lin H., Kirino Y., Sakaguchi Y., and Suzuki Ts.*:
“Complete chemical structures of human mitochondrial tRNAs”
Nat Commun. 11(1):4269. (2020)
Press Release (RIKEN)
Press Release (The University of Tokyo)
Recommended in Faculty Opinions

Nakazawa K. Shichino Y., Iwasaki S., and Shiina N.*:
“Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation”
J Biol Chem. 295(44):15029-15044. (2020)
Press Release (RIKEN)
Press Release (NIBB)

Fujita T., Yokoyama T., Shirouzu M., Taguchi H., Ito T., and Iwasaki S.*:
“Anatomy of footprint extension in ribosome profiling reveals translational landscape mediated by S1 protein in bacteria"
Research Square. (2020)

Saeki N., Eguchi Y., Kintaka R., Makanae K., Shichino Y., Iwasaki S., Kanno M., Kimura N., and Moriya H.*:
“N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae”
Sci Rep. 10(1):9500. (2020)

Han P., Shichino Y., Schneider-Poetsch T., Mito M., Hashimoto S., Udagawa T., Kohno K., Yoshida M., Mishima Y., Inada T., and Iwasaki S.*:
“Genome-wide survey of ribosome collision”
Cell Rep. 31(5):107610. (2020)
BioRxiv. (2019)
Press Release

Tsuboyama K.*, Osaki T., Matsuura-Suzuki E., Kozuka-Hata H., Okada Y., Oyama M., Ikeuchi Y., Iwasaki S., and Tomari Y.*:
“A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation”
PLoS Biol. 18(3):e3000632. (2020)
BioRxiv. (2019)
Press Release (The University of Tokyo)
Media

Yokoi S*, Naruse K, Kamei Y, Ansai S, Kinoshita M, Mito M, Iwasaki S., Inoue S, Okuyama T, Nakagawa S, Young LJ, and Takeuchi H.*:
“Sexually dimorphic role of oxytocin in medaka mate choice”
Proc Natl Acad Sci USA. 117(9):4802-4808. (2020)

Kurihara Y., Makita Y., Shimohira H., Fujita T., Iwasaki S., and Matsui M.*:
“Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis”
Plant Cell Physiol. 61(3):536-545. (2020)
Press Release

Hia F., Yang SF., Shichino Y., Yoshinaga M., Murakawa Y., Vandenbon A., Fukao A., Fujiwara T., Landthaler M., Natsume N., Adachi S., Iwasaki S., and Takeuchi O.*:
“Codon bias confers stability to human mRNAs”
EMBO Rep. 20(11):e48220. (2019)
BioRxiv. (2019)

Padrón A., Iwasaki S., and Ingolia NT.*:
“Proximity RNA labeling by APEX-Seq reveals the organization of translation initiation complexes and repressive RNA granules”
Mol Cell. 75(4):875-887. (2019)
BioRxiv. (2018)

Hirayama H., Matsuda T., Tsuchiya Y., Oka R., Seino J., Huang C., Nakajima K., Noda Y., Shichino Y., Iwasaki S., and Suzuki T.*:
“Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast”
J Biol Chem. 294(44):15900-15911. (2019)
Selected as "Editors' Picks Highlights"
Press Release

Fujita T., Kurihara Y.*, and Iwasaki S.*:
“The plant translatome surveyed by ribosome profiling”
Plant Cell Physiol. 60(9):1917-1926. (2019)
Selected as "Editor's choice"

Mito M., Kadota M., Nakagawa S., and Iwasaki S.*:
“tChIP-Seq: cell-type-specific Eepigenome profiling”
J Vis Exp. 143:e58298. (2019)

Iwasaki S.*, Iwasaki W., Takahashi M. (equal contribution), Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*:
“The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA”
Mol Cell. 73(4):738-748.e9 (2019)
Press Release
Recommended in Faculty Opinions

Akichika S., Hirano S. (equal contribution), Shichino Y., Suzuki Ta., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O.*, and Suzuki Ts.*:
“Cap-specific terminal N⁶-methylation of RNA by an RNA polymerase II–associated methyltransferase”
Science. 363(6423):eaav0080. (2019)
Press Release (RIKEN)
Press Release (The University of Tokyo)
Press Release (Nikkei)
Recommended in Faculty Opinions

Komatsu T., Yokoi S., Mito M., Fujii K., Kimura Y., Iwasaki S., and Nakagawa S.*:
“UPA-Seq: Prediction of functional lncRNAs using differential sensitivity to UV crosslinking”
RNA. 24(12):1785-1802. (2018)
BioRxiv (2018)

Kurihara Y., Makita Y., Kawashima M., Fujita T., Iwasaki S., and Matsui M.*:
“Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis”
Proc Natl Acad Sci USA. 115(30):7831-7836 (2018)
Highlighted by COMMENTARY
Press Release
Recommended in Faculty Opinions

Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.*:
“Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing”
Sci Rep. 8:1143. (2018)
BioRxiv. (2017)
Press Release

Iwasaki S. and Tomari Y.*:
“Reconstitution of RNA interference machinery”
Methods Mol Biol.1680:131-143. (2018)

Naruse K., Matsuura-Suzuki E. (equal contribution), Watanabe M., Iwasaki S.*, and Tomari Y.*:
“In vitro reconstitution of chaperone-mediated human RISC assembly”
RNA. 24(1):6-11. (2018)

Matsuo Y., Ikeuchi K. (equal contribution), Saeki, Y., Iwasaki S., Schmidt C., Udagawa T., Sato F., Tsuchiya H., Becker T., Tanaka K., Ingolia NT., Beckmann R., and Inada T.*:
“Ubiquitination of stalled ribosome triggers ribosome-associated quality control”
Nat Commun. 8(1):159. (2017)

Iwasaki S.* and Ingolia NT.*:
“The Growing toolbox for protein synthesis studies”
Trends Biochem Sci. 42(8):612-624. (2017)

Ishikawa K., Makanae K., Iwasaki S., Ingolia NT., and Moriya H.*:
“Post-translational dosage compensation buffers genetic perturbations to stoichiometry of protein complexes”
PLoS Genet. 13(1):e1006554. (2017)
Press Release (Okayama University)
News (QLifePro)

Iwasaki S. and Ingolia NT.*:
“PROTEIN TRANSLATION. Seeing translation”
Science. 352(6292):1391-2. (2016)

Iwasaki S., Floor SN., and Ingolia NT.*:
“Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor”
Nature. 534(7608):558-61. (2016)

Werner A., Iwasaki S., Teerikorpi N., Fedrigo I., Ingolia NT., and Rape M.*:
“Cell-fate determination by ubiquitin-dependent regulation of translation”
Nature. 525(7570):523-7. (2015)

Iwasaki S., Sasaki MH. (equal contribution), Sakaguchi Y., Suzuki T., Tadakuma H.*, and Tomari Y.*:
“Defining fundamental steps in the assembly of Drosophila RNAi enzyme complex”
Nature. 521(7553):533-6. (2015)
Press Release

Kwak PB., Iwasaki S. (equal contribution), and Tomari Y.*:
“The microRNA pathway and cancer”
Cancer Sci. 101(11), 2309-15 (2010)

Iwasaki S., Kobayashi M. (equal contribution), Yoda M., Sakaguchi Y., Katsuma S., Suzuki T., and Tomari Y.*:
“Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes”
Mol Cell. 39(2):292-9. (2010)
Recommended in Faculty Opinions

Yoda M., Kawamata T., Paroo Z., Ye X., Iwasaki S., Liu Q., and Tomari Y.*:
“ATP-dependent human RISC assembly pathways”
Nat Struct Mol Biol. 17(1):17-23. (2010)

Iwasaki S., and Tomari Y.*:
“Argonaute-mediated translational repression (and activation)”
Fly (Austin). 3(3):204-6. (2009)

Iwasaki S., Kawamata T., and Tomari Y.*:
“Drosophila Argonaute1 and Argonaute2 employ distinct mechanisms for translational repression”
Mol Cell. 34(1):58-67. (2009)
Journal Cover
Recommended in Faculty Opinions

Takeda A., Iwasaki S., Watanabe T., Utsumi M., and Watanabe Y.*:
“The mechanism selecting the guide strand from small RNA duplexes is different among Argonaute proteins”
Plant Cell Physiol. 49(4):493-500. (2008)

Iwasaki S., Takeda A., Motose H., and Watanabe Y.*:
“Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development”
FEBS Lett. 581(13):2455-9. (2007)

Japanese Reviews: 2023-current
岩崎信太郎:
“翻訳開始因子eIF4Aを標的とする翻訳阻害剤”
生化学 96(3): 336-347. (2024)
戸室幸太郎、藤博貴、岩崎信太郎:
"リボソームプロファイリング法の拡張によるトランスレイトームの多面的理解"
実験医学 41(15):2369-2375. (2023)

Japanese Reviews: 2022
岩崎信太郎, 吉田稔:
"スプライシング阻害と翻訳制御"
生化学 94(6):819-828. (2022)
松浦絵里子, 岩崎信太郎:
"リボソームタンパク質の修飾と翻訳制御"
細胞 54(12):684-687. (2022)
市原知哉, 岩崎信太郎, 松本有樹修:
"未注釈ORFの同定とその生理機能"
実験医学 40(12):2003-2010. (2022)
岩崎信太郎:
“ダイソームプロファイリング法によるリボソーム衝突の網羅探索”
生化学 94(1):87-91. (2022)

Japanese Reviews: 2017-2021
七野悠一, 岩崎信太郎:
“RNP顆粒研究を加速するトランスクリプトーム解析技術”
相分離生物学の全貌 (東京化学同人) 368-372. (2020)
木村悠介, 岩崎信太郎:
“リボソームプロファイリングによる網羅的翻訳解析の最前線”
実験医学 37(18):3055‐3057. (2019)
岩崎信太郎:
“eIF4A阻害の多様なメカニズム”
生化学 90(2):211‐215. (2018)
七野悠一, 岩崎信太郎:
“リボソームプロファイリングが切り拓く翻訳研究の未来”
実験医学 35(11):1868‐1873. (2017)

Japanese Reviews: 2010-2016
岩崎信太郎:
“小分子rocaglateは翻訳開始因子eIF4AをRNA配列に対し選択的な翻訳抑制因子に変える”
新着論文レビュー (2016)
岩崎信太郎:
“ncRNA判定法 (リボソームプロファイリング)”
ノンコーディングRNA RNA分子の全体像を俯瞰する (化学同人) 181-191. (2016)
岩崎信太郎, 佐々木浩, 泊幸秀:
“再構成系および1分子観察により同定されたショウジョウバエにおけるRISCの形成の過程”
新着論文レビュー (2015)
岩崎信太郎, 泊幸秀:
“small RNA二本鎖のATP依存的なRISC積み込み反応はHsc70/Hsp90シャペロンマシナリーによって媒介される”
新着論文レビュー (2010)